
In 2009, Chopra founded the Chopra Foundation, a tax-exempt 501(c) organization that raises funds to promote and research alternative health. In 2012, Chopra joined the board of advisors for tech startup, creating a browsable network of structured opinions. In 2014, Chopra founded ISHAR (Integrative Studies Historical Archive and Repository). In 2015, Chopra partnered with businessman Paul Tudor Jones II to found JUST Capital, a non-profit firm which ranks companies in terms of just business practices in an effort to promote economic justice. Medical anthropologist Hans Baer said Chopra was an example of a successful entrepreneur, but that he focused too much on serving the upper-class through an alternative to medical hegemony, rather than a truly holistic approach to health. As of 2005, according to Srinivas Aravamudan, he was able to charge $25,000 to $30,000 per lecture five or six times a month.

Chopra himself is estimated to be worth over $80 million as of 2014. A year's worth of products for 'anti-ageing' can cost up to $10,000, Offit wrote. In his 2013 book, Do You Believe in Magic?, Paul Offit writes that Chopra's business grosses approximately $20 million annually, and is built on the sale of various alternative medicine products such as herbal supplements, massage oils, books, videos and courses. Sharp HealthCare changed ownership in 1996 and Chopra left to set up the Chopra Center for Wellbeing with neurologist David Simon, now located at the Omni La Costa Resort and Spa in Carlsbad, California. Chopra's treatments generally elicit nothing but a placebo response, and have drawn criticism that the unwarranted claims made for them may raise 'false hope' and lure sick people away from legitimate medical treatments. Evolutionary biologistRichard Dawkins has said that Chopra uses 'quantum jargon as plausible-sounding hocus pocus'.

This has led physicists to object to his use of the term quantum in reference to medical conditions and the human body.

Chopra argues that what he calls 'quantum healing' cures any manner of ailments, including cancer, through effects that he claims are literally based on the same principles as quantum mechanics. Philosopher Robert Carroll states Chopra attempts to integrate Ayurveda with quantum mechanics to justify his teachings. This criticism has been described as ranging 'from dismissive damning'. The ideas Chopra promotes have been regularly criticized by medical and scientific professionals as pseudoscience.
